Every formulation at OvertopHealth begins in peer-reviewed literature. We don't create a product until the evidence base is sufficient to justify clinical use.
Our Scientific Advisory Board reviews emerging literature quarterly. A new ingredient must meet three criteria before we consider formulation: a minimum of three independent RCTs, a mechanistic explanation for efficacy, and published bioavailability data.
We then develop internal studies in partnership with our Singapore R&D facility and Nanyang Technological University before committing to commercial production.
Systematic review of PubMed, Cochrane Library, and EFSA databases. Minimum 3 independent RCTs required.
Biochemical pathway must be established. We don't proceed on association alone—causal mechanisms must be identified.
Internal absorption studies conducted at our Singapore facility. Triglyceride form vs ethyl ester vs phospholipid form tested.
Independent IFOS-certified laboratory validates purity, potency, and safety before commercial release.
Ongoing customer outcome tracking and quarterly batch re-testing maintain quality standards post-launch.
Key studies supporting our formulations. All citations link to original publications on PubMed or journal archives.
DPA-rich seal oil supplementation produced significant reductions in aortic pulse-wave velocity compared to fish oil controls. Effect size: 0.42 (p<0.001).
Read on PubMed ›Pooled analysis of 11 RCTs confirms 73% superior plasma incorporation of triglyceride-form omega-3 at 24-hour post-dose measurement.
Read on PubMed ›Double-blind RCT (n=240). 12-month DHA supplementation significantly improved working memory scores and reduced IL-6 inflammatory markers.
Read on PubMed ›Marine algae calcium (Lithothamnion calcareum) demonstrated equivalent calcium retention to dairy calcium with superior tolerability and no constipation adverse events.
Read on PubMed ›Systematic review of 24 studies establishes DPA as an independent cardiovascular biomarker, mediating effects on platelet aggregation and endothelial function.
Read on PubMed ›RCT (n=160 infants). MFGM-supplemented formula group showed significantly higher scores on Bayley cognitive and language scales at 12 months.
Read on PubMed ›Cohort study (n=2500, 15-year follow-up). Omega-3 Index above 8% associated with 34% lower all-cause mortality risk versus Index below 4%.
Read on PubMed ›Head-to-head crossover study confirms seal oil omega-3 phospholipid form achieves 68% greater red blood cell membrane incorporation versus fish oil ethyl esters.
Read on PubMed ›DPA serves as a metabolic reserve, rapidly converting to EPA or DHA under physiological demand—a unique property absent from plant-source omega-3s.
Read on PubMed ›From strategic formulation in Houston to anti-cancer research in Germany, fundamental discovery in Toronto and applied science in Auckland — four specialist R&D centers drive every formula we make.
Strategic formulation & clinical translation
Fundamental research & molecular discovery
Anti-cancer & regenerative medicine research
Applied science & marine bioactive sourcing
Every batch is independently verified before it reaches you. We publish the results because transparency isn't optional in health science.